S.E.M.I.: Side Effects May Include... box art

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S.E.M.I.: Side Effects May Include... (2026)

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S.E.M.I. is a cooperative online game about escaping from a special clinic. Here you and up to 3 of your feeble-minded loyal friends in the role of patients fight with the staff and other patients and find yourself in unexpected situations. Teamwork is essential, as randomized events and experimental drugs will lead your party into unpredictable mayhem. Pop pills with your friends as you cooperate to gain your freedom.

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Details

Developers: Two Horn Unicorn
Publishers: Two Horn Unicorn
Genres: Arcade, Hack and slash/Beat 'em up, Indie
Themes: Action, Comedy, Party
Event: INDIE Live Expo 2025.11.29
Steam: View on Steam

Release dates

Nov 20, 2025 (Early Access) (Worldwide) PC (Microsoft Windows)
Jan 23, 2026 (Full Release) (Worldwide) PC (Microsoft Windows)

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